Dr. Anna Marie Pyle is a Yale Sterling Professor, in the Department of Molecular, Cellular and Developmental Biology and the Department of Chemistry. She has been an HHMI investigator since 1997. Dr. Pyle co-discovered the RIG-I receptor family and she conducted many of the first structural and biochemical investigations on RIG-I.  Dr. Pyle is also a specialist in RNA structure, synthesis, and design.  She designed the SLRs for selective targeting of RIG-I, and developed them as antitumor and anticancer compounds in collaboration with Dr. Iwasaki.   Dr. Pyle has designed other types of bioactive RNA molecules for studies of RNA processing and protein recognition.