RIGImmune’s mission is to create a new class of therapies that harness the body’s own immune system to better fight off viral diseases and cancer.
RIGImmune is developing best-in-class host targeted immune activating therapies utilizing novel Stem Loop RNA (SLRs) molecules. The SLRs are formulated as broad-spectrum antivirals and immuno-oncology therapeutics in proprietary non-LNP tissue-targeted delivery technology.
RIGImmune has also developed an advanced respiratory drug delivery capability with a proprietary platform formulation technology for specific delivery of mRNA, DNA, and oligonucleotides of diverse size and structure without the need for lipid nanoparticle (LNP) encapsulation.
Our lead candidate RIG-101 has an initial focus on pre- and post-exposure prophylaxis of respiratory viral infections in high-risk patient populations and as a broad-spectrum vaccine adjuvant for respiratory diseases with high unmet clinical needs.
Our core technology is designed to target a pattern recognition receptor called cytosolic RNA RIG-I, which plays a critical role as sentinel in activation of the innate immune system. RIG-I is key to our body’s natural defense against viral infection. When viral RNA enters our cells, the cells’ natural defense responds rapidly by activating sensor proteins that trigger RIG-I and our innate immune system.
Our SLRs are designed to mimic the physiological double-stranded viral RNA ligands for RIG-I that are released during viral infection. They act as rapid, specific and potent activators of retinoic acid-inducible gene I (RIG-I), our first line of defense as a cytosolic innate immune sensor. The innate immune system utilizes host encoded nucleic acid sensors known as pattern recognition receptors (PRRs). RIG-I is one such PRR that mediates viral RNA recognition and initiates front line anti-viral defense through Interferon-1 dependent and independent mechanisms.
RIGimmune’s novel SLRs harness and control RIG-I, enabling the patients’ own immune system to fight diseases and provide rapid improvement and sustained effects.